The method of iontophoresis was described by Pivati in 1747.Galvani and Volta, two well-known scientists working in the 18th century, combined the knowledge that electricity can move different metal ions, and that movements of ions produce electricity. The method of administrating pharmacological drugs by iontophoresis became popular at the beginning of the 20th century due to the work of Leduc (1900) who introduce the word iontotherapy and formulated the laws for this process.