Sensitive skin is a large-area, flexible array of sensors with data processing capabilities, which can be used to cover the entire surface of a machine or even a part of a human body. Depending on the skin electronics, it endows its carrier with an ability to sense its surroundings via the skin’s proximity, touch, pressure, temperature, chemical/biological, or other sensors. Sensitive skin devices will make possible the use of unsupervised machines operating in unstructured, unpredictable surroundings among people, among many obstacles, outdoors on a crowded street, undersea, or on faraway planets. Sensitive skin will make machines “cautious” and thus friendly to their environment. This will allow us to build machine helpers for the disabled and elderly, bring sensing to human prosthetics, and widen the scale of machines’ use in service industry. With their ability to produce and process massive data flow, sensitive skin devices will make yet another advance in the information revolution. This paper surveys the state of the art and research issues that need to be resolved in order to make sensitive skin a reality.